Evaluation of the Efficacy and Cross-Protectivity of Recent Human and Swine Vaccines against the Pandemic (H1N1) 2009 Virus Infection
Identifieur interne : 001106 ( Main/Exploration ); précédent : 001105; suivant : 001107Evaluation of the Efficacy and Cross-Protectivity of Recent Human and Swine Vaccines against the Pandemic (H1N1) 2009 Virus Infection
Auteurs : Philippe Noriel Q. Pascua [Corée du Sud] ; Min-Suk Song [Corée du Sud] ; Jun Han Lee [Corée du Sud] ; Kuk Jin Park [Corée du Sud] ; Hyeok-Il Kwon [Corée du Sud] ; Yun Hee Baek [Corée du Sud] ; Seung-Pyo Hong [Corée du Sud] ; Jong-Bok Rho [Corée du Sud] ; Chul-Joong Kim [Corée du Sud] ; Haryoung Poo [Corée du Sud] ; Thomas S. Ryoo [Corée du Sud] ; Moon-Hee Sung [Corée du Sud] ; Young Ki Choi [Corée du Sud]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Abstract
The current pandemic (H1N1) 2009 virus remains transmissible among humans worldwide with cases of reverse zoonosis, providing opportunities to produce more pathogenic variants which could pose greater human health concerns. To investigate whether recent seasonal human or swine H1N1 vaccines could induce cross-reactive immune responses against infection with the pandemic (H1N1) 2009 virus, mice, ferrets or mini-pigs were administered with various regimens (once or twice) and antigen content (1.77, 3.5 or 7.5 µg HA) of a-Brsibane/59/07, a-CAN01/04 or RgCA/04/09xPR8 vaccine. Receipt of a-CAN01/04 (2-doses) but not a-Brisbane/59/07 induced detectable but modest (20–40 units) cross-reactive serum antibody against CA/04/09 by hemagglutinin inhibition (HI) assays in mice. Only double administration (7.5 µg HA) of both vaccine in ferrets could elicit cross-reactivity (30–60 HI titers). Similar antigen content of a-CAN01/04 in mini-pigs also caused a modest ∼30 HI titers (twice vaccinated). However, vaccine-induced antibody titers could not suppress active virus replication in the lungs (mice) or virus shedding (ferrets and pigs) of immunized hosts intranasally challenged with CA/04/09. Furthermore, neither ferrets nor swine could abrogate aerosol transmission of the virus into naïve contact animals. Altogether, these results suggest that neither recent human nor animal H1N1 vaccine could provide complete protectivity in all animal models. Thus, this study warrants the need for strain-specific vaccines that could yield the optimal protection desired for humans and/or animals.
Url:
DOI: 10.1371/journal.pone.0008431
PubMed: 20037716
PubMed Central: 2793524
Affiliations:
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Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Bioleaders Corporation, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Chul Joong" sort="Kim, Chul Joong" uniqKey="Kim C" first="Chul-Joong" last="Kim">Chul-Joong Kim</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>College of Veterinary Medicine, Chungnam National University, DaeJeon, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungnam National University, DaeJeon</wicri:regionArea><wicri:noRegion>DaeJeon</wicri:noRegion></affiliation></author><author><name sortKey="Poo, Haryoung" sort="Poo, Haryoung" uniqKey="Poo H" first="Haryoung" last="Poo">Haryoung Poo</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Korean Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korean Research Institute of Bioscience and Biotechnology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Ryoo, Thomas S" sort="Ryoo, Thomas S" uniqKey="Ryoo T" first="Thomas S." last="Ryoo">Thomas S. Ryoo</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Prestige World Genetics, Genetics Korea, Ltd., Pyongtaek, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Prestige World Genetics, Genetics Korea, Ltd., Pyongtaek</wicri:regionArea><wicri:noRegion>Pyongtaek</wicri:noRegion></affiliation></author><author><name sortKey="Sung, Moon Hee" sort="Sung, Moon Hee" uniqKey="Sung M" first="Moon-Hee" last="Sung">Moon-Hee Sung</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Bioleaders Corporation, Daejeon, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Bioleaders Corporation, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Young Ki" sort="Choi, Young Ki" uniqKey="Choi Y" first="Young Ki" last="Choi">Young Ki Choi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20037716</idno><idno type="pmc">2793524</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793524</idno><idno type="RBID">PMC:2793524</idno><idno type="doi">10.1371/journal.pone.0008431</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000A97</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A97</idno><idno type="wicri:Area/Pmc/Curation">000A97</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A97</idno><idno type="wicri:Area/Pmc/Checkpoint">000A60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A60</idno><idno type="wicri:Area/Ncbi/Merge">000466</idno><idno type="wicri:Area/Ncbi/Curation">000466</idno><idno type="wicri:Area/Ncbi/Checkpoint">000466</idno><idno type="wicri:Area/Main/Merge">001115</idno><idno type="wicri:Area/Main/Curation">001106</idno><idno type="wicri:Area/Main/Exploration">001106</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of the Efficacy and Cross-Protectivity of Recent Human and Swine Vaccines against the Pandemic (H1N1) 2009 Virus Infection</title><author><name sortKey="Pascua, Philippe Noriel Q" sort="Pascua, Philippe Noriel Q" uniqKey="Pascua P" first="Philippe Noriel Q." last="Pascua">Philippe Noriel Q. Pascua</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Song, Min Suk" sort="Song, Min Suk" uniqKey="Song M" first="Min-Suk" last="Song">Min-Suk Song</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jun Han" sort="Lee, Jun Han" uniqKey="Lee J" first="Jun Han" last="Lee">Jun Han Lee</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Park, Kuk Jin" sort="Park, Kuk Jin" uniqKey="Park K" first="Kuk Jin" last="Park">Kuk Jin Park</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Kwon, Hyeok Il" sort="Kwon, Hyeok Il" uniqKey="Kwon H" first="Hyeok-Il" last="Kwon">Hyeok-Il Kwon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Baek, Yun Hee" sort="Baek, Yun Hee" uniqKey="Baek Y" first="Yun Hee" last="Baek">Yun Hee Baek</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Hong, Seung Pyo" sort="Hong, Seung Pyo" uniqKey="Hong S" first="Seung-Pyo" last="Hong">Seung-Pyo Hong</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Bioleaders Corporation, Daejeon, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Bioleaders Corporation, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Rho, Jong Bok" sort="Rho, Jong Bok" uniqKey="Rho J" first="Jong-Bok" last="Rho">Jong-Bok Rho</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Bioleaders Corporation, Daejeon, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Bioleaders Corporation, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Chul Joong" sort="Kim, Chul Joong" uniqKey="Kim C" first="Chul-Joong" last="Kim">Chul-Joong Kim</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>College of Veterinary Medicine, Chungnam National University, DaeJeon, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungnam National University, DaeJeon</wicri:regionArea><wicri:noRegion>DaeJeon</wicri:noRegion></affiliation></author><author><name sortKey="Poo, Haryoung" sort="Poo, Haryoung" uniqKey="Poo H" first="Haryoung" last="Poo">Haryoung Poo</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Korean Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korean Research Institute of Bioscience and Biotechnology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Ryoo, Thomas S" sort="Ryoo, Thomas S" uniqKey="Ryoo T" first="Thomas S." last="Ryoo">Thomas S. Ryoo</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Prestige World Genetics, Genetics Korea, Ltd., Pyongtaek, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Prestige World Genetics, Genetics Korea, Ltd., Pyongtaek</wicri:regionArea><wicri:noRegion>Pyongtaek</wicri:noRegion></affiliation></author><author><name sortKey="Sung, Moon Hee" sort="Sung, Moon Hee" uniqKey="Sung M" first="Moon-Hee" last="Sung">Moon-Hee Sung</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Bioleaders Corporation, Daejeon, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Bioleaders Corporation, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Young Ki" sort="Choi, Young Ki" uniqKey="Choi Y" first="Young Ki" last="Choi">Young Ki Choi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The current pandemic (H1N1) 2009 virus remains transmissible among humans worldwide with cases of reverse zoonosis, providing opportunities to produce more pathogenic variants which could pose greater human health concerns. To investigate whether recent seasonal human or swine H1N1 vaccines could induce cross-reactive immune responses against infection with the pandemic (H1N1) 2009 virus, mice, ferrets or mini-pigs were administered with various regimens (once or twice) and antigen content (1.77, 3.5 or 7.5 µg HA) of a-Brsibane/59/07, a-CAN01/04 or RgCA/04/09xPR8 vaccine. Receipt of a-CAN01/04 (2-doses) but not a-Brisbane/59/07 induced detectable but modest (20–40 units) cross-reactive serum antibody against CA/04/09 by hemagglutinin inhibition (HI) assays in mice. Only double administration (7.5 µg HA) of both vaccine in ferrets could elicit cross-reactivity (30–60 HI titers). Similar antigen content of a-CAN01/04 in mini-pigs also caused a modest ∼30 HI titers (twice vaccinated). However, vaccine-induced antibody titers could not suppress active virus replication in the lungs (mice) or virus shedding (ferrets and pigs) of immunized hosts intranasally challenged with CA/04/09. Furthermore, neither ferrets nor swine could abrogate aerosol transmission of the virus into naïve contact animals. Altogether, these results suggest that neither recent human nor animal H1N1 vaccine could provide complete protectivity in all animal models. Thus, this study warrants the need for strain-specific vaccines that could yield the optimal protection desired for humans and/or animals.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Nicholls, H" uniqKey="Nicholls H">H Nicholls</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, J" uniqKey="Cohen J">J Cohen</name></author><author><name sortKey="Enserink, M" uniqKey="Enserink M">M Enserink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name></author><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name></author><author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name></author><author><name sortKey="Shaw, Mw" uniqKey="Shaw M">MW Shaw</name></author><author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, T" uniqKey="Ito T">T Ito</name></author><author><name sortKey="Couceiro, Jn" uniqKey="Couceiro J">JN Couceiro</name></author><author><name sortKey="Kelm, S" uniqKey="Kelm S">S Kelm</name></author><author><name sortKey="Baum, Lg" uniqKey="Baum L">LG Baum</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholtissek, C" uniqKey="Scholtissek C">C Scholtissek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, W" uniqKey="Ma W">W Ma</name></author><author><name sortKey="Kahn, Re" uniqKey="Kahn R">RE Kahn</name></author><author><name sortKey="Richt, Ja" uniqKey="Richt J">JA Richt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohr, K" uniqKey="Stohr K">K 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Franks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aiyar, A" uniqKey="Aiyar A">A Aiyar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Jd" uniqKey="Thompson J">JD Thompson</name></author><author><name sortKey="Gibson, Tj" uniqKey="Gibson T">TJ Gibson</name></author><author><name sortKey="Plewniak, F" uniqKey="Plewniak F">F Plewniak</name></author><author><name sortKey="Jeanmougin, F" uniqKey="Jeanmougin F">F Jeanmougin</name></author><author><name sortKey="Higgins, Dg" uniqKey="Higgins D">DG Higgins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perriere, G" uniqKey="Perriere G">G Perriere</name></author><author><name sortKey="Gouy, M" uniqKey="Gouy M">M Gouy</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Pascua, Philippe Noriel Q" sort="Pascua, Philippe Noriel Q" uniqKey="Pascua P" first="Philippe Noriel Q." last="Pascua">Philippe Noriel Q. Pascua</name></noRegion><name sortKey="Baek, Yun Hee" sort="Baek, Yun Hee" uniqKey="Baek Y" first="Yun Hee" last="Baek">Yun Hee Baek</name><name sortKey="Choi, Young Ki" sort="Choi, Young Ki" uniqKey="Choi Y" first="Young Ki" last="Choi">Young Ki Choi</name><name sortKey="Hong, Seung Pyo" sort="Hong, Seung Pyo" uniqKey="Hong S" first="Seung-Pyo" last="Hong">Seung-Pyo Hong</name><name sortKey="Kim, Chul Joong" sort="Kim, Chul Joong" uniqKey="Kim C" first="Chul-Joong" last="Kim">Chul-Joong Kim</name><name sortKey="Kwon, Hyeok Il" sort="Kwon, Hyeok Il" uniqKey="Kwon H" first="Hyeok-Il" last="Kwon">Hyeok-Il Kwon</name><name sortKey="Lee, Jun Han" sort="Lee, Jun Han" uniqKey="Lee J" first="Jun Han" last="Lee">Jun Han Lee</name><name sortKey="Park, Kuk Jin" sort="Park, Kuk Jin" uniqKey="Park K" first="Kuk Jin" last="Park">Kuk Jin Park</name><name sortKey="Poo, Haryoung" sort="Poo, Haryoung" uniqKey="Poo H" first="Haryoung" last="Poo">Haryoung Poo</name><name sortKey="Rho, Jong Bok" sort="Rho, Jong Bok" uniqKey="Rho J" first="Jong-Bok" last="Rho">Jong-Bok Rho</name><name sortKey="Ryoo, Thomas S" sort="Ryoo, Thomas S" uniqKey="Ryoo T" first="Thomas S." last="Ryoo">Thomas S. Ryoo</name><name sortKey="Song, Min Suk" sort="Song, Min Suk" uniqKey="Song M" first="Min-Suk" last="Song">Min-Suk Song</name><name sortKey="Sung, Moon Hee" sort="Sung, Moon Hee" uniqKey="Sung M" first="Moon-Hee" last="Sung">Moon-Hee Sung</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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